Naïve T cells require two signals in order to be fully activated and undergo clonal expansion.

Here are the steps:

1. Signal 1: This is provided through the T cell receptor (TCR) which interacts with the peptide-MHC complex on the surface of the antigen presenting cell (APC). This signal ensures that the T cell is specific to the antigen presented.

2. Signal 2: This is also known as co-stimulation and is provided by the interaction of co-stimulatory molecules expressed on the surface of the APC and the T cell. The most well-known co-stimulatory molecules are B7 family members (CD80 and CD86) on the APC that interact with CD28 on the T cell. This signal confirms that the antigen is a pathogen and not a self-antigen.

Both signals are required for full activation of the T cell. If the T cell only receives signal 1, it can become anergic or undergo apoptosis.

Question

Naïve T cells require two signals in order to be fully activated and undergo clonal expansion.

Here are the steps:

1. Signal 1: This is provided through the T cell receptor (TCR) which interacts with the peptide-MHC complex on the surface of the antigen presenting cell (APC). This signal ensures that the T cell is specific to the antigen presented.

2. Signal 2: This is also known as co-stimulation and is provided by the interaction of co-stimulatory molecules expressed on the surface of the APC and the T cell. The most well-known co-stimulatory molecules are B7 family members (CD80 and CD86) on the APC that interact with CD28 on the T cell. This signal confirms that the antigen is a pathogen and not a self-antigen.

Both signals are required for full activation of the T cell. If the T cell only receives signal 1, it can become anergic or undergo apoptosis.

Knowee AI · Accepted Answer

Naïve T cells require two signals in order to be fully activated and undergo clonal expansion.

Here are the steps:

1. Signal 1: This is provided through the T cell receptor (TCR) which interacts with the peptide-MHC complex on the surface of the antigen presenting cell (APC). This signal ensures that the T cell is specific to the antigen presented.

2. Signal 2: This is also known as co-stimulation and is provided by the interaction of co-stimulatory molecules expressed on the surface of the APC and the T cell. The most well-known co-stimulatory molecules are B7 family members (CD80 and CD86) on the APC that interact with CD28 on the T cell. This signal confirms that the antigen is a pathogen and not a self-antigen.

Both signals are required for full activation of the T cell. If the T cell only receives signal 1, it can become anergic or undergo apoptosis.

Naïve T cells require_____ signals in order to be fully activated and undergo clonal expansion.2431

Question

Naïve T cells require _____ signals in order to be fully activated and undergo clonal expansion.2431

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