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A mutation denoted as : p.Gly551Asp can also be denoted as :c.551G>AG551Dp.Gly551p.Asp551Gly

Question

A mutation denoted as:

p.Gly551Asp can also be denoted as:

  • c.551G>AG
  • 551Dp.Gly551
  • p.Asp551Gly
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Solution

The mutation p.Gly551Asp refers to a change in the protein sequence where the amino acid glycine (Gly) at position 551 is replaced by aspartic acid (Asp).

This can also be denoted in several other ways:

  • c.551G>A: This notation is used to indicate changes at the DNA level. The "c." stands for "coding DNA sequence". Here, it means that the guanine (G) at position 551 is replaced by adenine (A).

  • G551D: This is a simplified version of the protein-level notation. It simply means that glycine (G) at position 551 is replaced by aspartic acid (D).

  • p.Gly551: This notation refers to the original amino acid (glycine) at position 551 in the protein sequence.

  • p.Asp551: This notation refers to the new amino acid (aspartic acid) at position 551 in the protein sequence after the mutation.

  • Gly551Asp: This is another simplified version of the protein-level notation. It simply means that glycine (Gly) at position 551 is replaced by aspartic acid (Asp).

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